rev protein การใช้

• The Psi element is involved in viral genome packaging and recognized by Gag and Rev proteins.
• The RRE also facilitates multimerization of the Rev proteins, which is required for Rev binding and function.
• Other therapies target the Rev protein itself, since it is an essential component of HIV-1 infection.
• In common with other lentiviruses, the FIV genome encodes additional short open reading frames ( ORFs ) encoding the Vif and Rev proteins.
• One of these small, 2kb messages encodes the HIV-1 Rev protein which is imported into the nucleus via its nuclear localization sequence.
• NES signal was
  鹯st discovered in the human immunode
  鹀iency virus type 1 ( HIV-1 ) Rev protein and cAMP-dependent protein kinase inhibitor ( PKI ).
• If delivered to cells, Rev M10 will compete with the wild-type Rev protein for the RRE binding site, and therefore decrease Rev s normal cellular functions.
• Rev is required for expression of unspliced or partially spliced mRNA coding for the viral envelope protein, including " gag " and " env " in a similar manner as the HIV Rev protein.
• During viral replication, the integrated DNA provirus is Rev . As the newly produced Rev protein accumulates in the nucleus, it binds to full-length, unspliced copies of virus RNAs and allows them to leave the nucleus.
• The mouse mammary tumor virus ( MMTV ) has formerly been classified as a simple retrovirus; however, it has recently been established, that MMTV encodes an extra self-regulatory mRNA export protein, Rem, with resemblance to the Human Immunodeficiency Virus HIV Rev protein, and is therefore the first complex murine retrovirus to be documented.